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The Most Measured Pregnancy
Kayla Barnes-Lentz · Open data · Updated Oct 4, 2026

The Most Measured Pregnancy

I have spent years publicly tracking my health in more detail than any woman on the planet. Now I am turning my pregnancy into the most measured individual pregnancy ever publicly documented, and sharing the data here, free, so any woman can learn from it. Conceived naturally in September 2026.

Gestational age
5w1d
from last period, Aug 29
Trimester
First
weeks 1 to 13
Due date
Jun 5
2027 · ultrasound will refine
Days to go
244
13% of the way
you are here ▾
1st · wk 1–132nd · wk 14–273rd · wk 28–40
The scale

Thousands of biomarkers across 26 systems

Pregnant women are among the most excluded groups in medical research. Standard prenatal care relies on a short list of routine screening tests, checked a handful of times. This project measures 26 of the 31 systems in my longevity protocol, everything that can be safely measured in pregnancy.

1000s
of biomarkers, including proteomics
26/31
systems in my longevity protocol, all that can be safely measured in pregnancy
1M+
data points across the pregnancy
2M+
data points through postpartum
Latest results · week 4–5

Confirmation labs

The first blood work after a positive test. Both numbers are right where a healthy early pregnancy should be.

β-hCGSep 30
960mIU/mL
On track for ~5 weeks

The pregnancy hormone. In early pregnancy it roughly doubles every 48 to 72 hours, so a repeat draw comes next to confirm the rise.

Serum progesteroneSep 30
39.6ng/mL
01st-tri range 11.0–44.350

Strong, in the upper part of the first-trimester range. For context, my follicular-phase level in June was 0.4 and my luteal level in September was 12.7.

At-home urine hormonesSince Sep 28
Trending up
On track

Daily first-morning readings of progesterone and estrogen metabolites are rising, as expected in early pregnancy. Day-to-day swings mostly reflect hydration, so I read the trend, not single days.

Week 1 recap · Sep 29 to Oct 5 · 4w3d to 5w2d

Week 1: steady blood sugar, a slower gut, and the first nausea

My first full week of measured pregnancy, compared with my own pre-pregnancy baseline from this summer.

97.7%
glucose time in range, same as baseline
91
mg/dL on Oct 4, my lowest day since July
34%
firm stools, up from 6%
+0.42°
peak temperature, Oct 4
Oct 6
nausea begins at 5w3d
Daily average glucose
101mg/dL
week 1 average · baseline 104.5
1,801 readings
daily average (open = sensor days 1–2)pre-pregnancy baseline

Blood sugar stayed 97.7% in range with no lows, the same as before pregnancy, and drifted down across the week. That fits early pregnancy, when insulin sensitivity rises. The first two days were the sensor's first days, when CGMs often read a little high, so they are shown lighter.

Normal in early pregnancyLower glucose in the first trimester is expected. Rising estrogen and progesterone increase insulin sensitivity, so cells take up glucose more readily, and the growing placenta and baby draw a steady supply from the mother's blood. Fasting glucose typically falls in early pregnancy. Later, placental hormones make the body more insulin resistant, which is why glucose screening happens at 24 to 28 weeks.
Digestion (Throne)
32stools
Sep 30 to Oct 6
firmer week
healthyfirmlooseliquid
Baseline weekWeek 1
Per day2.44.6
Healthy53%47%
Firm6%34%

A firm stool every day from Oct 1, the day after my progesterone came back at 39.6. Progesterone slows the gut, one of the most common early pregnancy changes. Oct 6 is a partial day.

Normal in early pregnancyFirmer stools and slower digestion are among the most common early changes. Progesterone relaxes smooth muscle throughout the body, including the gut, so food moves through more slowly and more water is absorbed, which firms the stool. Iron in prenatal vitamins can add to this. Fiber, water, and daily movement help.
Saliva cortisol (Eli)
Optimalcortisol curve
Oct 7 · morning and evening in range
high morning, low night
02468~7 ng/mL at waking<0.5 ng/mL at night04:5410:0015:0020:12

Cortisol should peak shortly after waking and fall to its lowest point by evening. The slope between the two readings is the signal, not either number alone.

Normal in pregnancyTotal cortisol rises steadily across pregnancy, driven largely by hormones from the placenta, and can reach two to three times pre-pregnancy levels by the third trimester. The daily rhythm, high in the morning and low at night, is normally preserved, which is why I track the shape of the curve over time.

Next: from mid-October, these numbers become my true pregnancy baseline to track week by week. Temperature, HRV and resting heart rate for the same week are in the Oura charts below.

Daily wearables · Oura ring

What the body showed before any test did

Continuous data from my last period onward, refreshed every morning. Latest night: Oct 3.

Body temperature vs. baseline
+0.42°C
latest night
Elevated since Sep 16
nightly deviationafter the temperature shift

Temperature dropped with my period on Aug 29, then rose on Sep 16 once progesterone took over after ovulation. In a typical cycle it falls again about two weeks later. This time it stayed up and kept climbing, peaking at +0.38 °C on Oct 1. That sustained rise is one of the earliest signs of pregnancy you can see from a wearable.

Heart rate variability
—ms
7-night average
7-night averagenightly
Resting heart rate
—bpm
7-night average
7-night averagenightly

Blood volume starts expanding within weeks of conception, and the heart works a little harder to move it. Resting heart rate has drifted up and HRV has eased down. This is expected physiology, and I will track how far it goes across each trimester and how quickly it returns after birth.

Day 0 · locked Sep 28, 2026

The pre-pregnancy baseline

A full snapshot from the weeks before conception. Every change across the next nine months gets measured against this starting line.

Reproductive

AMH
6.24 ng/mL
Luteal progesterone (serum)
12.7 ng/mL
Cycles
regular, ovulatory

Metabolic

HbA1c
5.2%
Fasting insulin
4.0 µIU/mL
Glucose (lab)
89 mg/dL
CGM average (Jul–Aug)
106 mg/dL
CGM time in range
99%
Uric acid
3.6 mg/dL

Thyroid

TSH
1.17 mIU/L
Free T3
3.3 pg/mL
Free T4 index
2.3
TPO antibodies
<1 neg
Thyroglobulin antibodies
<2 neg

Cardiovascular

ApoB
100 mg/dL
LDL
124 mg/dL
Total cholesterol
212 mg/dL
Non-HDL
141 mg/dL
Triglycerides
55 mg/dL
Lp(a)
86 nmol/L
hs-CRP
<0.2 mg/L
Homocysteine
5.8 µmol/L

Lipids from my Jul 7 draw, now my pre-pregnancy baseline.

Nutrients & iron

Vitamin D 25-OH
109 ng/mL
Ferritin
158 ng/mL
Transferrin saturation
48%
Iron
125 µg/dL
B12
1179 pg/mL
Folate
>24 ng/mL

Well stocked going in. Iron and folate needs climb steeply in pregnancy.

Organs & blood count

ALT / AST / GGT
15 / 19 / 7
Creatinine
0.70 mg/dL
eGFR
116
Albumin
5.1 g/dL
Hemoglobin
12.9 g/dL
WBC / Platelets
5.4 / 220

Inflammation & immune

ESR
2 mm/h
ANA
negative
Rheumatoid factor
<10
Immune health age
25 10 yrs younger

Environment

Blood mercury
7 µg/L <11
Urine mycotoxins (Jun)
clean

Biological age

Chronological age
35
Organ age, overall
25
Cardiovascular age
−11.5 yrs

One of the big questions: does pregnancy move these numbers, and how fast do they return?

The protocol

Measurement by rhythm

Layered testing, from continuous sensors to once-a-pregnancy deep panels.

Continuous

Every day

  • Continuous glucose monitor
  • Oura: sleep, HRV, resting heart rate, temperature
  • Mira urine hormones (PdG, E3G, LH, hCG), daily in the 1st trimester
  • Home blood pressure
Weekly

Every week

  • Saliva cortisol, morning and evening, 2–3 day cluster
  • Weight
  • Mira tapers to 1–2× a week in the 2nd trimester
Monthly

Blood work

  • Full blood panel: CBC, CMP, lipids, hs-CRP
  • Full hormone panel
  • Full thyroid panel
  • Fasting insulin + HbA1c
  • Iron panel and micronutrients
  • Vitamin D + calcium
At home, weekly

Body & function

  • Grip strength
  • Lung capacity (peak flow, FEV1)
  • Body composition by bioimpedance (no DEXA while pregnant)
  • Waist and waist-to-hip
  • Balance and sit-to-stand
  • Brain function (cognitive testing)
Each trimester

Deeper layer

  • Gut and vaginal microbiome
  • Biological and organ age
  • Mycotoxins, heavy metals, and the exposome (PFAS, phthalates, BPA)
  • Immune clock of pregnancy
  • A daily cortisol baseline week
  • Mood screen (EPDS)
Frontier

Newest tests

  • Proteomics measuring thousands of proteins, from baseline through postpartum
  • Preeclampsia and preterm prediction from cell-free RNA
  • sFlt-1/PlGF preeclampsia ratio
  • Functional placental MRI + cervical elastography
  • At-home fetal and maternal monitoring
Every test

The full testing plan

All planned tests, grouped from standard care to research frontier. Status updates as results come in.

Most of my monthly blood work runs through SuperpowerSign up with my link and save.Sign up & save →
TestWhenLab or toolStatus
Why measure

The questions I want to answer for women

  1. Does pregnancy age you, and do you bounce back?
  2. How do hormones actually move, week by week?
  3. What does healthy blood sugar look like in pregnancy?
  4. How does the immune system reprogram across pregnancy?
  5. How do the gut and vaginal microbiomes shift, and how does a mother seed her baby?
  6. What toxins actually cross the placenta?
  7. How do sleep, HRV, and recovery change as you grow a baby?
  8. When do nutrient needs really spike?
  9. Can we see preeclampsia and preterm birth coming before symptoms?
  10. How does the thyroid behave across pregnancy?
  11. What does postpartum recovery look like, measured?
  12. Which at-home tests can you trust?
  13. How does a woman's heart change and recover?
  14. What is the full data map of one healthy pregnancy?
  15. What can you control, and what is simply biology?
A measured day

Daily routine

How testing, food, and movement fit into one day in the first trimester. Shared for transparency, not as a recommendation.

Wakebefore water or coffee
  • Mira first-morning urine, then saliva cortisol within 30–60 min of waking
  • Blood pressure after 5 seated minutes, fasting glucose from the CGM, overnight Oura review
Breakfastprotein first
  • Protein, fiber, slow carbs, and berries
  • Caffeine kept under ~200 mg a day (I am a slow caffeine metabolizer)
Movementmid-morning
  • Pregnancy-safe strength training and Zone 2, conversational pace, staying cool and hydrated
  • Weekly functional and brain tests happen on the same day each week; monthly blood draws are fasted
Lunchplants + fiber
  • Protein, fiber, colorful plants
  • Berries, cacao, olive oil for polyphenols
Dinnerearly evening
  • 80–100 g protein across the day. This is a season to nourish.
Eveningwind down
  • Evening saliva cortisol (the morning-to-evening slope is the signal)
  • Dim lights, cool room, consistent bedtime
THE FEMALE LONGEVITY PROTOCOL™

The Female Longevity Protocol™, the first protocol library built specifically for female biology, by Kayla Barnes-Lentz.

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MEDICAL DISCLAIMER: This website, including any experimental results presented, is for informational purposes only and does not constitute medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease. Individuals seeking medical advice should consult with a licensed physician.